Lawrence Moon
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>Spinal Cord Injury >Stroke >Pathology and Repair
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Three most cited papers: (cited >3,500 times in total)

Bradbury EJ, Moon LDF, Popat RJ, King VR, Bennett GS, Patel PN, Priestley JV, Fawcett JW, McMahon SB (2002) Chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury.  Nature 416:636-40.

Moon LDF, Asher RA, Rhodes KE, Fawcett JW (2001) Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC. Nature Neuroscience 4:465-466.

Thuret S, Moon LDF and Gage FH (2006) Therapeutic strategies for SCI. Nature Reviews Neuroscience 7:628-643.

Other papers and abstracts (chronologically):

Duricki DA, Drndarski S, Bernanos M, Wood T, Bosch K, Chen Q, Shine HD, Simmonds C, Williams SCR, McMahon SB, Begley DJ, Cash D and Moon LDF (2019) Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion Annals of Neurology 85:32-46. Our BioRxiv version has no restriction on manuscript length and therefore has a more complete methods section.

Hutson TH, Kathe C, Palmisano I, Bartholdi K, Hervera A, De Virgilis F, McLachlan E, Zhou L, Kong G, Barraud Q, Danzi MC, Medrano-Fernandez A, Lopez-Atalaya JP, Boutillier A, Sinha SH, Singh AK, Chaturbedy P, Moon LDF, Kundu TK, Bixby JL, Lemmon VP, Barco A, Courtine G and Di Giovanni S (2019) Cpb-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Science Translational Medicine. 11:eaaw2064.

Kakanos S and Moon LDF (2019) Delayed peripheral treatment with neurotrophin-3 improves sensorimotor recovery after central nervous system injury. Neural Regeneration Research: 4(10):1703-1704. doi:10.4103/1673-5374.257518

Fletcher EJR, Moon LDF and Duty S (2019) Chondroitinase ABC reduces nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson's disease. BMC Neuroscience 20:61

Duricki DA, Wayman C, Haenzi B, Cash D, & Moon LDF (2018) Dexterity, cutaneous sensation and walking improves in elderly rats treated 24 hours after large focal strokes with subcutaneous neurotrophin-3. BioRxiv doi:

Kathe C and Moon LDF (2018) RNAseq dataset describing transcriptional changes in cervical sensory ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy for AAV1 encoding human neurotrophin-3. BioRxiv: 415877 and published at Data In Brief although the BioRxiv version is better.

Moon LDF (2018) Chromatolysis: do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA? Developmental Neurobiology doi: 10.1002/dneu.22625.

Spejo AB and Moon LDF (2018) An Intriguing way to enhance rehabilitation of grasping in rats after spinal cord injury. Brain 141:1888-1899.

Moon LDF and Bradbury EJ (2018) 'Chase': in dogged pursuit of a therapy for spinal cord injury. Brain 141:941-943.

Curtis MJ, Ashton JC, Moon LDF and Ahluwalia A (2018) Clarification of the basis for the selection of requirements for publication in the British Journal of Pharmacology BJP 175:3633-3635.

Jeffery ND, Bate ST, Safayi S, Howard MA, Moon L, Jeffery U (2018) When neuroscience met clinical pathology: partitioning experimental variation to aid data interpretation in neuroscience. European Journal of Neuroscience 47:371-379.

Percie du Sert N, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill IC, Fry D, Karp NA, Macleod M, Moon L, Stanford SC, Lings B. (2017) The Experimental Design Assistant. Nature Methods 14:1024-1025. doi: 10.1038/nmeth.4462.

Percie du Sert N, Alfieri A, Allan SM, Carswell HVO, Deuchar GA, Farr TD, Flecknell F, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LDF, O’Neill MJ, Perez de Puig I, Planas A, Ragan IC, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R and Macrae IM. (2017) The IMPROVE Guidelines (Ischaemia
Models: Procedural Refinements Of in Vivo Experiments)
Journal of Cerebral Blood Flow and Metabolism Jan 1:271678X17709185.

Percie du Sert N, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill I, Fry D, Karp NA, Macleod M, Moon LDF, Stanford SC, Lings B. (2017) The Experimental Design Assistant. PLoS Biol. 15:e2003779.

Haenzi B and Moon LDF (2017) The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury. Neural Plasticity Article ID 2740768, 13 pages, 2017. doi:10.1155/2017/2740768

Callahan A and the FAIR Share Workshop Participants (2017) Developing a data sharing community for spinal cord injury research. Experimental Neurology 295:135-143.

Moon LDF (2017) How to save time and reduce frustration when writing manuscripts by using customised Captions to manage the numbering, citation and renaming of Supplementary Materials. Figshare 4516826

Kathe C, Hutson TH, McMahon SB and Moon LDF (2016) Intramuscular Neurotrophin-3 normalizes
low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats
. eLife 5:e1814

Duricki DA, Soleman S and Moon LDF (2016) Analysis of longitudinal (repeated measures) from anmials where some data are missing by fitting linear models with general error covariance structures using the MIXED procedure in SPSS. Nature Protocols 11:1112-1129.

Gadiagellan D, Nakayakkara T, Moon LDF (2016) The in-cage automation of a test for dexterity after stroke. Society for Neuroscience Abstracts.

Haenzi B, Gers-Barlag K, Akhoundzadeh H, Hutson TH, Menezes S and Moon LDF (2016) Overexpression of FGFR1 in a model of spinal cord injury in rats. PLOS One 11(3): e0150541.

Harrison B, Venkat G, Lamb J, Hutson T, Drury C, Hill C, Rau K, Bunge MB, Mendell L, Gage F, Johnson RD, Rouchka E, Moon LDF,and Petruska JC (2016) The Adaptor Protein CD2AP is a Coordinator of Neurotrophin Signalling-Mediated Axon Arbour Plasticity. Journal of Neuroscience 36:4259–4275.

Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska J, Shine HD, Chen Q, Wood T, Bernanos M, Cash D, Williams S, Gage FH and Moon LDF (2016) Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain 139; 259–275.

Hutson TH, Kathe C and Moon LDF (2016) Trans-neuronal transduction of spinal neurons following cortical injection and anterograde axonal transport of a bicistronic AAV1 vector. Gene Therapy 23, 231–236.

Moon LDF (2015) Let's be certain about sartans. Brain 138:3132-3140.

Wayman C, Duricki DA, Roy LA, Haenzi B, Tsai SY, Karje G, Beech J, Cash D, Moon LDF. (2015) Performing permanent distal middle cerebral artery occlusion with common carotid occlusion in aged rats to study cortical ischemia with sustained disability. Journal of Online Visualized Experiments. e53106.

Harrison BJ, Venkat G, Hutson T, Rau KK, Bunge MB, Mendell LM, Gage FH, Johnson RD, Hill CE, Rouchka EC, Moon LDF and Petruska JC (2015) Transcriptional changes in sensory ganglia associated with primary afferent collateral sprouting in spared dermatome model. Genomics Data 6:249-252.

Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SPA, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LDF, Wonnacott S, Weston AH and McGrath J (2015) Experimental Design and analysis and their reporting: new guidance for publication in BJP. British Journal of Pharmacology 172:3461-3471.

Kathe C, Hutson TH, Chen Q, Shine HD, McMahon SB and Moon LDF (2014) Unilateral pyramidotomy of the corticospinal tract in rats for assessment of neuroplasticity-inducing therapies. Journal of Online Visualized Experiments (JOVE) Dec 15;(94). doi: 10.3791/51843.

Hutson TH, Kathe C, Menezes SC, Rooney M-C, Bueler H and Moon LDF (2014) The use of an adeno-associated viral vector for efficient bicistronic expression of two genes in the central nervous system. Methods in Molecular Biology. 1162:189-207.

Lemmon VP and the MIASCI consortium (2014) Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma 15:1354-1361.

Flight RM, Harrison BJ, Mohammad F, Bunge MB, Moon LDF, Petruska JP, Rouchka EC (2014) CategoryCompare, an analytical tool based on feature annotations. Frontiers in Genetics 5:98 1-13.

Hutson TH, Foster E, Moon LDF and Yanez-Munoz (2014) Lentiviral Vector-Mediated RNA Silencing
in the Central Nervous System.
Human Gene Therapy Methods 25:14–32

Jarrett W, Watts G, Allen C, Brazier M, Clark P, Deeny A, Lee N, Moon LDF, Robinson V, Taylor D, Wells D and Willis P. The Steering Group for the Concordat on Openness in Animal Research (2013) Alternatives to Laboratory Animals (ATLA) 41:195-196.

Steering Group member and co-author (2014) Concordat on Openness in Animal Research in the UK.

Kumar P and Moon LDF (2013) Therapeutics targeting Nogo-A hold promise for stroke restoration. CNS Neurol Disord Drug Targets 12:200-208.

Peluffo H, Foster E, Ahmed SG, Lago N, Hutson TH, Moon LDF, Wanisch K, Caraballo-Miralles V, Olmos G, Llado J, McMahon SB and Yanez-Munoz RJ (2013) Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord. Gene Therapy 20:645-657.

Buchser W, Smith RP, Pardinas JP, Haddox CL, Hutson TH, Moon, LDF, Hoffman SR, Bixby JL and Lemmon VP (2012) Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates. PLOS One: 7:e38101.

Soleman S, Yip, P, Duricki D and Moon LDF (2012) Delayed treatment with Chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats. Brain 135:1210-1223.

Hutson TH, Foster E, Dawes JM, Hindges R, Yanez-Munoz R, Moon LDF (2012) Lentiviral vectors encoding shRNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and
cytotoxicity in CNS neurons.
Journal of Gene Medicine 7: 299-315.

Hutson TH, Verhaagen J, Yanez-Munoz RJ and Moon LDF (2012) Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector. Gene Therapy 19:49-60. 

Hutson TH, Buchser WJ, Bixby JL, Lemmon VP and Moon LDF (2011) Optimization of a 96-well electroporation assay for postnatal rat CNS neurons suitable for cost-effective medium-throughput screening of genes that promote neurite outgrowth. Frontiers in Molecular Neuroscience. 4:1-11.

Thomas KE and Moon LDF (2011) Will stem cell therapies be safe and effective for treating spinal cord injuries? British Medical Bulletin - Advance online publication.

Soleman S, Yip P, Leasure JL and Moon LDF (2010) Sustained sensorimotor deficit after cerebral ischemia (stroke) in aged rats. Experimental Neurology 222 13–24.

Duricki DA, Hutson TH, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Gage FH, Cash D, Moon LDF (2010) Recovery of aged rats treated 24 hours after stroke by intramuscular NT3 gene therapy. Society for Neuroscience Abstracts. 353.1.

Moon LDF(*), Hutson TH (*), van Kesteren R, Iffland K, Torres-Muñoz J, Petito C, Bowen C, Aimone JB, Buchser W, Lemmon VP, Bixby JL, Smit AB, Gage FH and Bunge MB (2010) Identification of molecules that promote re-growth of injured nerve fibers by laser microdissection of in vivo regenerating spinal neurons. Christopher and Dana Reeve Foundation's International meeting, Phoenix, USA.

Soleman S, Yip P, Duricki D, Leasure JL and Moon LDF (2009) Delayed treatment with chondroitinase ABC improves forelimb deficits produced by endothelin-1 induced cerebral ischemia (stroke) in aged rats. Society for Neuroscience Abstracts 739.10.

Hutson TH, Buchser W, Lemmon VP, Bixby JL, McMahon SB and Moon LDF(2009) Enhancing neurite outgrowth: Use of 96-well electroporation to screen regeneration associated genes. Society for Neuroscience Abstracts

Thacker MA, Clark AK, Bishop T, Grist J, Yip PK, Moon LDF, Thompson SWN, Marchand F and McMahon SB (2009) CCL2 is a key mediator of microglia activation in neuropathic pain states. European Journal of Pain 13: 263-272.

Moon LDF and King A (2009) Animal models of disease and injury: a new in vivo based module for 2nd year students at King's College London. British Pharmacological Society Abstracts P072.

Moon LDF (2008) What is it like to use rats in neurobiological research? The Biochemist October 2008 pp30-31.

Petruska JC, Moon LDF, Lee Y, Bunge MB, Mendell L. Changes in NGF- and pain-related genes during collateral sprouting revealed by microarray analysis. Society for Neuroscience Abstracts 2006.

Moon LDF, Madani R, Vassalli, J-D., Bunge MB (2006) Neuronal overexpression of tissue-type plasminogen activator does not enhance sensory axon regeneration or locomotor recovery following dorsal hemisection of adult mouse thoracic spinal cord. Journal of Neuroscience Research 84:1245-1254.

Thuret et al., Corrigendum

Moon LDF, Leasure JL, Gage FH and Bunge MB (2006) Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. Restorative Neurology and Neuroscience 24:147-161.

Hill CE, Moon LDF, Wood PW, Bunge MBB (2006) Labeled Schwann cell transplantation: Cell loss, host Schwann cell replacement, and strategies to enhance survival. Glia 53:338-343.

Hurtado A, Moon LDF, Maquet V, Blits B, Jerome R, Oudega M (2006) Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord.  Biomaterials 27:430-42.

Moon LDF & Bunge MB (2005) From animal models to humans: strategies for promoting CNS axon regeneration and recovery of limb function after spinal cord injury. Journal of Neurological Physical Therapy 29:55-69.

Oudega M, Moon LDF, Leme R. (2005) Schwann cells for spinal cord repair. Brazilian Journal of Medical and Biological Research 38:825-835.

Aimone JB, Leasure JL, Perreau VM, Thallmair M, The Christopher Reeve Paralysis Foundation Research Consortium.  (2004).  Spatial and temporal gene expression profiling of the contused rat spinal cord.  Experimental Neurology 189:204-21.

Moon LDF, Asher RA, Fawcett JW (2003) Limited increase in sprouting of severed CNS axons following treatment of adult rat brain with hyaluronidase. Journal of Neuroscience Research 71:23-37.

Rhodes KE, Moon LDF, Fawcett JW  (2003) Inhibiting cell proliferation during formation of the glial scar:  effects on axon regeneration in the CNS. Neuroscience 120:41-56.

Moon LDF, Asher RA, Rhodes KE, Fawcett JW (2002) Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat. Neuroscience 109:101-117.

Moon LDF, Fawcett JW (2001) Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to transforming growth factors b1 and b2.  European Journal of Neuroscience 14:1667-1677.

Asher RA, Morgenstern DA, Moon LDF, Fawcett JW (2001) Chondroitin sulphate proteoglycans: inhibitory components of the glial scar. Progress in Brain Research 132:611-619

Moon LDF, Brecknell JE, Franklin RJ, Dunnett SB, Fawcett J.W. (2000) Robust regeneration of CNS axons through a track depleted of CNS glia. Experimental Neurology 161:49-66.


Suggested reading

Moon et al., 2001

Thuret et al., 2006

Bradbury et al., 2002